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  • Home
  • ABOUT
    • History
    • UAPA EXECUTIVE BOARD & COMMITTEES
    • Operational Guidelines
    • Contact
  • Postdoc Life
    • Spotlight
    • UAPA Postdoc Handbook
    • National Postdoctoral Association
    • Useful Links
  • Professional Development
  • Events
  • Get Involved

Dr. Michel De Keersmaecker – Department of Chemical and Environmental Engineering

5/3/2022

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Many of us have noticed lately that prices of many products have skyrocketed. The world is facing an unprecedented energy crisis because it heavily depends on fossil fuels that have become scarce due to the COVID-19 struggles and geopolitical tensions. At the heart of this problem lies the slow energy transition that needs to transform the global energy sector from fossil-based to zero-carbon. Decarbonization will be critical not only to supply the continuously increasing energy demand, but more importantly to reduce energy-related CO2 emissions to limit climate change. The only solution will be a combination of various renewable energy technologies going from photovoltaic cells to batteries and solar fuels. Fundamentally, most of these technologies are based on (photo)electrochemical processes, which is my main scientific background.

My passion for science, and chemistry more specifically, and curiosity for the unknown started right after high school and it has been a constant motivation throughput my career since then. As a result, I received my PhD in 2015 at Ghent University in Belgium by developing new corrosion protection treatments for metallic objects, gaining expertise in different fields going from electrochemistry and surface analysis to materials science. After my PhD, I had to make one of the hardest decisions in my life when I left my family to accept an offer for a postdoctoral position sponsored by the Office of Naval Research at the Georgia Institute of Technology in the Reynolds Research Group. Next to adapting a completely new lifestyle, I also switched from working with metals to semiconductors, which geared my research to the world of semiconductor electrochemistry. I quickly realized that the fundamentals for many renewable technologies required an often ignored and/or incorrectly used deep electrochemical background, which started my crusade for teaching the correct science to students. Thrown in the world of conjugated polymers, I engineered novel transparent electrodes and device structures for electrochromic devices but was also involved in understanding ion-electron conducting mechanisms, internal resistances and charging effects within redox-active devices for applications such as supercapacitors and switchable elements for frequency-agile antennas. I am convinced that this work in combination with absorbing much of the knowledge from other group members on organic photovoltaics, conjugated polymer synthesis and device manufacturing makes me to the mature scientist I am today.

​In 2020, I decided to move even further west to the University of Arizona to work under the supervision of Dr. Erin Ratcliff and Dr. Neal Armstrong on the electrochemical processes within optoelectronic devices to solve stability, manufacturing, and characterization problems, which remain the main issue for their further commercialization. Critical to understand degradation processes, I have been developing electrochemical approaches to study the defect (electro)chemistry in material and device stacks with unprecedented detection limits under operating conditions. Overall, the advanced electrochemical characterization platform we created is crucial towards the search for low cost, improved and stable (opto)electronic materials to realize industry-scalable technologies in the field of photovoltaics, charge storage systems, photoelectrochemical cells, etc. This platform I developed has led me to improve my experiences as an inventor and to start competing for research funding. My goal is to pursue highly impactful studies that will help and accelerate the development of renewable technologies to reach our 100% clean energy future.
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Dr. Jules Moutet – Department of Chemistry and Biochemistry

4/4/2022

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​I am a French chemist imported on US soil with a deep interest in research from macro- to micro- scopic scale. During my scientific career, I had the chance to be educated in different complementary fields of life sciences. This has allowed me to develop a constant curiosity for the complex mechanisms at work in living being as well as the deep laws governing matter.

In 2014 this appetence for knowledge led me to pursue a PhD in France at the University of Grenoble Alpes with the Dr. Nicolas Leconte, where my thesis encompassed research at the interface between organic and inorganic chemistry. The multidisciplinarity approach that I took, based on links between various fields such as biology, analytical chemistry and catalysis resulted in the development of bio-inspired oxidation catalysts. In parallel, I have also developed stable radical complexes of transition metals, the novelty of which has led me to sharpen my skills in characterizing transient and exotic chemical species.

The pressing environmental crisis facing humanity drove me to join the research group of Pr. Greg Nocton at École Polytechnique in Paris during 2018. As a post-doctoral researcher, I was involved in the development of a project for the reprocessing and valorization of polluting gases from human activity (CO, CO2, CH4). Catalysts using the specific characteristics of the f-elements (lanthanides) of the periodic table and their synergy with abundant transition metals have been published. In order to improve my team management skills, I was in charge of the supervision of the facilities as well as of the PhD and Master students. The confidence and trust of this mentor led me to develop on my own a molecular qubit topic for quantum computing via a more physical approach to my research and resulted in the report of the first Single Molecule Magnet of divalent Thulium.

The imperative need to decrease the human impact on our planet and to accelerate the transition to a sustainable, decarbonized and more ethical economy brought me to the University of Arizona in January 2020 as a post-doctoral research assistant in Prof. Thomas L. Gianetti's group. Since then, I have been actively involved in the laboratory's research on the development of organic photocatalysts capable of synthesizing active drug compounds without toxic metals and with high chemical compatibility. A significant part of my time is dedicated to training graduate students, managing the crucial equipment of the laboratory and writing grant proposals. On a more entrepreneurial side, I have also developed an innovative and competitive electrochemical energy storage project, which has resulted in publications and several patents as well as the co-founding of the company CarbeniumTec LLC. Our fully organic symmetrical redox flow battery approach has already produced promising results by overcoming the geostrategic metals and toxicity risks associated with electrochemical storage.
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Beyond research, through my various professional experiences, I desire to bring high standards of caring, mentoring and safety in the work environment. I strongly believe that science quality requires an increased focus on inclusiveness and diversity in higher education. The transmission of knowledge and the accompaniment in the educational process are for me priorities to succeed in training the researchers and teachers of tomorrow. I hope that my dynamism, my unceasing curiosity, and the network I have built will favor multidisciplinary collaborations. Interactions with international research groups will contribute to the dissemination of knowledge and increase the visibility of chemistry at the University of Arizona.
In an effort to balance my life with the intensity of my research work and the position of Chief Technical Officer at CarbeniumTec LLC, I enjoy the time I can devote to my hobbies such as motorcycling, hiking (inlove with Mt. Lemon) and being a dog, plants dad. If the sustainable redox flow battery project speaks to you visit our site (https://www.carbeniumtec.com/) and if you want to discuss science find me on LinkedIn (https://www.linkedin.com/in/jules-moutet-aab84141/).
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Dr. Jules Moutet received the Honorable Mention for the 2022 Outstanding Postdoctoral Scholar Award.
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Dr. Lila Wollman - Department of Physiology

3/17/2022

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     My broad research interest is to study how plasticity of the central nervous system occurs during development, disease, and aging. I have specifically focused on studying motor control using translational models of disease, an interest highly influenced by my background as a physical therapist. To me, the neuro-respiratory system is ideal for studying plasticity because breathing and related movements are easily observed and, because this system is critical for life, it has the capacity to express significant plasticity.
     I received my Master’s of Physical Therapy from Ithaca College in 2008 and worked as a physical therapist in an acute care hospital for four years, gaining expertise in critical care, orthopedic, and post-stroke therapy. As both a physical therapy student and during the time I spent working, I developed the desire to pursue a career in biological research that directly impacts human medicine and I decided to go back to school to get my Ph.D. In 2012, I entered the Physiological Sciences Graduate Interdisciplinary Program, here at the University of Arizona, and completed my PhD training under the guidance of Dr. Ralph Fregosi in 2017. After this, I accepted an NIH postdoctoral T32 fellowship and joined the laboratory of Dr. David Fuller, affiliated with the department of Physical Therapy and the research team at the Center for Respiratory Research and Rehabilitation at the University of Florida.

     In April 2019, I returned to Tucson and the University of Arizona as a postdoctoral research associate, again in Dr. Fregosi’s laboratory. Since then, I have been dedicated to the scientific focus of the lab, studying the effects of nicotine exposure on the development of respiratory motor control. Nicotine is a well-known neuroteratogen that adversely affects brain development through its actions on nicotinic acetylcholine receptors. Nicotinic acetylcholine receptors, which are expressed widely throughout the central nervous system, modulate fast-synaptic transmission and are important for mediating axon grown and synaptogenesis in early gestation. Previous work has shown that nicotine exposure during development results in changes to regions of the brainstem that control breathing and upper airway patency, including the hypoglossal motor neurons which innervate the muscles of the tongue. Changes to hypoglossal motor neurons, such as altered size and nicotinic acetylcholine receptor function, may contribute to obstructive apneas and other tongue control abnormalities that are associated with in utero nicotine exposure. Experiments from both my dissertation work and my postdoctoral work tested the hypothesis that nicotine exposure alters the development of fast-synaptic transmission to the hypoglossal motor neurons, which is a major determinant of the strength of motor output to the muscles of the tongue. Additionally, I tested the hypothesis that nicotine exposure during development alters the function of nicotinic acetylcholine receptors that act to modulate fast-synaptic transmission to hypoglossal motor neurons. For experiments in the lab, I use whole cell patch clamp recordings from hypoglossal motor neurons in a transverse slice of the medulla, and extracellular recordings from the fourth cervical ventral root in the brainstem-spinal cord preparation. All tissue preparations are from neonatal rats in the first week of life obtained from litters born to nicotine-exposed or unexposed dams. Overall, the results from these experiments elucidate specific mechanisms by which nicotine exposure may alter normal function of the respiratory neural network and lead to the breathing and tongue muscle control abnormalities that are observed in infants that are exposed to nicotine in utero.
     Along with my research in the lab, throughout my career, I have been committed to community outreach and fostering the next generation of scientists, with a strong commitment to supporting women in STEM, through my service with the American Physiological Society, local volunteer programs, formal teaching, and mentorship of a total of multiple undergraduate researchers. Since being back at the University of Arizona, among other things, I have been involved as a small group leader and the primary mentor for a student in the Undergraduate Biology Research Program (UBRP), I have volunteered for the Southern Arizona Research, Science and Engineering Foundation (SARSEF), I sought and received my Associate Level teaching certificate from the Center for the Integration of Research, Teaching, and Learning (CIRTL), and I had the great honor of being named a 2021 University of Arizona Sursum Fellow, and 2022 Outstanding Postdoctoral Scholar Award Honorable Mention. In addition, I have been planning my future directions and, ultimately, my transition to becoming an independent researcher. My long-term career objective is to obtain a tenure-track faculty position at a Level 1 research institution and establish an extramurally funded research program that is focused on neuroplasticity in respiratory-related neurons. I am currently working to achieve this goal by establishing an independent research program investigating the effects of nicotine withdrawal after chronic exposure on key neural structures involved in the ventilatory response to hypoxia, which is a critical respiratory chemoreflex. Over the past year, I have collected pilot data from this project which, last October, I submitted as an NIH K99/R00 Pathway to Independence award application. If awarded, I will spend significant time training at the University of Chicago and the University of Florida, which will allow me to bring new techniques and expertise to the physiology department here at the University of Arizona. 
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Dr. Lila Wollman received the Honorable Mention for the 2022 Outstanding Postdoctoral Scholar Award.
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Dr. Nicole Jimenez- Obstetrics and Gynecology at the College of Medicine Phoenix Campus

1/3/2022

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​I have always been naturally curious growing up in Arizona, so it is no wonder I ended up pursuing a career as a scientist.  I used to have jars of insects in my room, let my lunch items mold just to observe the changes, and was always outside making lists of birds, plants, and rocks. So I was lucky my mother put up with my curiosities and let me buy lots of books on different subjects growing up. My mother helped support my passions in life and as I got older I was inspired by my mentors from different programs like Si Se Puede Foundation and Arizona State University’s Los Diablos.  I saw people leading change in the community and people with similar cultural experiences as mine being Latinx clinicians and professors. I think it was a culmination of these things that really motivated me to pursue a career in science, to eventually be that person for others as well, and is part of my path that led me back here to University of Arizona. 
 
I recently defended my Ph.D. in Microbiology and Immunology at Virginia Commonwealth University in Richmond, Virginia this summer. My graduate work was centered on microbiome research working with VCU’s Vaginal Microbiome Consortium (VMC). My research for the VMC encompassed comparative genomics of cervicovaginal bacteria especially Bifidobacterium species, understanding correlations between the cervicovaginal microbiome in reproductive health and disease, as well as maternal-infant microbial transmission and toddler health progression. I joined Dr. Melissa Herbst-Kralovetz’s lab at University of Arizona’s College of Medicine-Phoenix July 2021 and have been using both my passion for advocacy work and science to assist with my research on the cervicovaginal microbiome.
 
 I am currently facilitating research as a postdoctoral researcher investigating the cervicovaginal microbiome and its role in endometrial cancer and gynecologic conditions like endometriosis. Specifically, I am utilizing my skills in microbiome analysis, microbial genomics, computational biology to better understand potential oncogenic bacteria and beneficial bacteria like Lactobacillus and their contributions to the cervicovaginal microenvironment in health and disease. I am also assisting in a collaborative project between Dr. Herbst-Kralovetz and Dr. Greg Caporaso’s group, creator of the popular Qiime2 microbiome software, from Northern Arizona University to look at the microbiome’s role in endometrial cancer, I am specifically analyzing the low-microbial biomass body site of the endometrium to validate our findings of this site. I am delighted to be part of Dr. Herbst-Kralovetz’s lab as we are currently using multi-omic approaches with immunoproteomics, metabolomics, and genomics in conjunction with the lab’s 3-D human cell models and large clinical studies to set the foundation for creation of innovative microbial biomarker diagnostics. In addition, our lab’s societal goals of expediting the research pipeline from bench to bedside tries to focus on health disparities within gynecologic conditions in context to Arizona’s diverse populations with many studies focusing on the Hispanic/Latinx, Native American, Aging communities. Thanks to Dr. Herbst-Kralovetz’s mentorship and collaboration, I was recently awarded a postdoctoral fellowship from the Community Foundation of Southern Arizona to begin work on studying three new bacteria that were recently classified as Atopobium vaginae, a key vaginal bacteria linked to the most common vaginal disorder bacterial vaginosis, that has also recently been associated with cervical and endometrial cancers. We hypothesize that there are different cancer-causing contributions amongst these three novel vaginal bacteria. Our first goal of this project is to analyze the “cancer-causing” potential of these newly identified bacteria using a well-characterized 3-D human endocervical cell model in the lab. While our second goal is to evaluate the clinical phenotypic presentation and microbiome relationship of these novel bacteria in two previously collected cervical and endometrial cancer cohorts. Potential clinical and immunometabolic differences seen from this study could impact early diagnostics and future clinical care of gynecologic cancers and provide insight into potential oncogenic mechanisms of bacteria that inhabit the cervicovaginal environment.
 
While much of my time is dedicated to my research, I also like to be heavily involved in different advocacy initiatives on and off campus. During my time at ASU (undergrad) and VCU(grad), I began advocating for science, STEM education, diversity, and mental health and well-being for the campus. These outside activities have taught me the importance of inclusivity in research and dissemination of science to the public. Although plenty busy with my research and advocacy work, I find time to unwind by playing intramural sports like dodgeball, hiking, crafting cocktails, cooking, reading, and being a cat mom. Want to chat about science or why Arizona is a great state, reach out via LinkedIn (https://www.linkedin.com/in/jimeneznr/) or follow me on Instagram(@Prettyfly4asci) and Twitter(@ScientistNicole).
 
 
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Dr. Sara Lewis- Child Health at the College of Medicine Phoenix Campus

12/8/2021

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Pediatric movement disorders, such as cerebral palsy and dystonia, are key contributors to childhood disability. There are major gaps in understanding underlying molecular pathways and responsible brain regions, meaning treatment and prevention options are seriously limited. My research uses patient-based gene discovery, bioinformatics, and model studies to identify changes underlying pediatric movement disorders.
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The Kruer laboratory has been instrumental in demonstrating the contributions of genetic etiologies to cerebral palsy. We found causative genes and pathways that significantly overlap with other neurodevelopmental disorders including intellectual disability, autism, and epilepsy. I used Drosophila to screen several of these candidate genes and verified they are necessary for normal locomotor performance. We are building on these findings in projects to characterize disease-associated variants and the normal function of several novel genes.

While studying dystonia-linked genes, I noticed similar defects in regulating eIF2α phosphorylation (eIF2α-P). This modification decreases protein translation to allow cells to recover from different types of stress. These initial observations led to an internal grant through Phoenix Children’s Hospital to develop an eIF2α-P genetic fly model that has locomotor impairments and dystonia-like movements. I am using the robust genetic toolkit of the fly model to identify whether changes to neuronal activity or synaptic connectivity contribute to dystonia and what cell types may contribute to hyperkinetic movements. To do this, I am utilizing studies of animal movements, biochemical changes, and anatomical and functional imaging.
I am also involved in several clinical projects. My mentor, Dr. Kruer, and I consult on efforts to identify novel treatment options for patients with ultra-rare conditions. I am leading a project for applying cerebral palsy genetic sequencing to clinical settings and building support for its implementation. I’ve contributed to writing reviews and position statements for reconciling genetic etiologies as a cause of cerebral palsy. My research on the cellular and molecular mechanisms of movement disorders are designed to support development of pharmaceutical and surgical interventions for treating these childhood disabilities. This efforts support my long-term goal to become a translational researcher in order to bridge the gaps needed for improving patient outcomes using research and advocacy.
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Dr. Minsik Hong – Department of Electrical and Computer Engineering

10/8/2021

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​My main research interest is autonomous systems and robotics as well as simulation technologies in medicine. During my Ph.D. studies and the postdoc period at the University of Arizona, I have mainly focused on development of medical robotic systems especially for minimally invasive surgery (MIS) training. MIS has been widely performed in the last three decades and is integrated into modern day surgical practice. Its advantages are widely acknowledged, with benefits of minimizing blood loss, post-operative pain, and reducing recovery time. However, this surgical technique is more challenging than open surgery and has a steeper learning curve. This is due to the need for special surgical instruments, laparoscopes and logistical issues of viewing the 3 dimensional (3D) operating field on a 2 dimensional (2D) digital display. Given the complexity of learning and performing MIS, it is required to develop novel simulation-based training systems which enhance training procedures in non-patient based settings.
I have been developing a novel training system called Computer-Assisted Surgical Trainer (CAST) for laparoscopic surgical skills training with my supervisor, Dr. Jerzy W. Rozenblit, through the NSF grant in Smart and Connected Health Program. As a lead researcher, I designed a visual and force guidance system as well as an assessment system to actively assist a trainee. Given a specific training task, CAST can provide visual and force guidance to assist a trainee using augmented reality (AR) rendering to convey depth information and fuzzy adaptive sliding mode controllers to adjust force feedback based on a trainee’s performance, respectively. Also, a scoring system with achievable goal-based evaluation metrics such as total time, idle time, average speed, path length, and direction profile has been developed to evaluate trainees’ performance objectively.
Currently, I am designing a “virtual coaching” system which provides personalized learning programs tailored to individual strengths and weaknesses for both standard laparoscopic surgery training and robotic surgery training. Computer-assistance in the form of guidance for manipulation of robotic arms or standard laparoscopic surgery instruments can be a step forward towards virtual coaching systems and, subsequently, improved and more efficient training. The novel guidance systems will ultimately improve patients’ safety as well as surgeons’ skills acquisition and maintenance.
During my master’s degree studies, I developed a mobile robot for mobile haptic interface in large immersive virtual environments. Based on the human-machine interaction research outcomes with current research outcomes in medicine, I am pursuing a robotic nursing assistant system through a Postdoctoral Research Development Grant. The COVID-19 pandemic has changed our lives in many ways. Especially, in hospitals, we may need robotic systems to assist healthcare workers by minimizing workers exposure to patients with the highly contagious virus. A robotic nursing assistant is envisioned to be an intelligent system which consists of sensing, perception, and actuation layers. The initial research of the robotic nursing system will be a basis for the future research. The novel robotic systems are not limited to medical domain but can also be applied for various applications such as space exploration and rescue operations. 
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​Dr. Minsik Hong was awarded a Postdoctoral Research Development Grant (PRDG) from the University of Arizona for a project titled “Robotic nursing assistant using a wheel-based robot with machine learning”. 
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Dr. Osmar Luiz Moreira P. F. Menezes - Department of Chemical and Environmental Engineering

9/16/2021

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​Organic pollutants (dyes, pesticides, explosives, pharmaceuticals, etc.) are constantly released into the environment due to human activities. Many of these compounds are xenobiotics, which means that microorganisms in nature have never seen them before (please, imagine Mariah Carey's "I don't know her" meme). Luckily, some microorganisms can adapt to this major inconvenience. For example, enzymes used for naturally occurring substrates can end up degrading a new contaminant in the environment. Alternatively, microorganisms can evolve and develop new specific enzymes to do that. However, microbes are not alone in nature or engineered systems (e.g., a biological reactor treating wastewater). Instead, they are surrounded – and affected to – by other microorganisms, water, nutrients, inert or reactive minerals, natural organic matter, gases, etc.  The organic contaminants and their biotransformation products (i.e., whatever the microbes transformed the contaminants to) can also react with these other components, affecting the contaminants' environmental fate and generating final products with different toxicity levels. Most of my experimental work (yes, it does involve long hours working at the lab bench) consists of breaking these complex environments into smaller pieces, which we call microcosms, to discover what chemical and biological phenomena are occurring after a new compound gets released in the environment. My research philosophy is to generate solutions to remediate environmental contamination by organic pollutants and, in the process, to find out how nature works.
This whole scientific journey started as a kid in my parents' backyard when I observed that the water with red ink that I had exhaustively extracted from a marker pencil became clear after passing it through a pot with soil (poor plants!). Years later, more formally, during my graduate studies at the Federal University of Pernambuco (Brazil), I initially worked with the treatment of azo dyes, which are largely released by the fashion industry in many aquatic environments. I optimized oxygen injection in a biological reactor to transform heavily contaminated textile wastewater into a non-toxic effluent. Next, I worked with the environmental remediation of explosive contaminants released on the soil by military activities, especially in four different topics: the ability of some reactive minerals in the soils and aquatic sediments to degrade explosives; the unusual phenomenon of soil bacteria making a living breathing an explosive; the (bio)degradation of a product of explosives compounds in contaminated wastewater; and the oligomerization reactions that lock the contaminant inside complex humic substances, which is a safe dead-end for some explosives in the environment.
During my postdoc at the University of Arizona, where I am supervised by Dr. Jim A. Field and Dr. Reyes Sierra-Alvarez, I am currently investigating the remediation of nitro-aromatics (including but not limited to explosives) using the soil natural organic matter's ability to shuttle electrons between biological and chemical systems in subsurface environments. The intense knowledge exchange with the brilliant people in the research group has made my research life fulfilling. Furthermore, it is evident to me how the new challenges and responsibilities as a postdoc are quickly preparing me for my career.
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Dr. Osmar Menezes was awarded a Postdoctoral Research Development Grant (PRDG) from the University of Arizona for a project titled “Soil Organic Matter Improves the Microbial Degradation of Emerging Contaminants”. 
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Dr. Caroline Machado Kopruszinski- Dept. pf Pharmacology

4/29/2021

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​As a post-doctoral fellow in the laboratory of Dr. Frank Porreca, my research has focused on studying orofacial pain.  My approach has been to use pharmacology, genetics and animal behavior. My professional goal is to establish a research program that focuses on the exploration of neural, immune and hormonal mechanisms that promote migraine pathophysiology disproportionally in women and to uncover mechanisms that can be exploited for the development of new therapies that will help patients suffering from this debilitating and often chronic condition.
Migraine is a common, disabling neurological disorder with a strong genetic component that impairs patients’ quality of life.  Currently available therapies are effective in less than half of people with migraine. During my post-doctoral period, I have published several studies on preclinical assessment of migraine and other underlying headache and craniofacial pain disorders with a goal of understanding mechanisms that may promote pain. One of the problems with preclinical studies of migraine is that we cannot replicate the genetic basis that underlies the human condition. For this reason, surrogate strategies have to be used to model the disorder mechanistically. I recently developed an injury-free model of migraine-like pain by evaluating the effect of inhalational exposure of umbellulone, an agonist at TRPA1 receptors that are found on afferent fibers innervating the cranial meninges.  Umbellulone is the major volatile constituent of Umbellularia californica, commonly known as the “headache tree”.  Anecdotal reports reveal that people with underlying primary headache disorders can develop migraine and cluster headache when exposed to the tree, likely from this volatile substance.  Importantly, however, people without headache disorders do not experience headache attacks with umbellulone suggesting a requirement for pre-existing vulnerability.  I approached this by subjecting mice to repeated episodes of stress, another known trigger of migraine, to induce vulnerability. Repeated episodes of stress induced a “sensitized” state in mice so that a normally subthreshold stimulus, i.e., umbellulone, now produced pain behaviors that were reminiscent of migraine-like pain. I then used this model to study possible mechanisms relevant to migraine and to investigate new anti-migraine therapies.  Using this model, I found that activation of the protease activated receptor 2 (PAR2) receptor could produce migraine-like pain in vulnerable animals and that systemic administration of a monoclonal PAR2 antibody could be an effective preventive migraine therapy. I am currently working with a major pharmaceutical company in their efforts to perform a clinical trial in migraine patients with this antibody.
Currently, I have been using genetically modified mice, CRISPR/Cas9 gene editing as well as opto- and chemogenetic methods to explore the peripheral and central neural circuits that can promote migraine pain and that might contribute to the sexually dimorphic nature of migraine. I have also focused on understanding of the neurobiology of the different phases of migraine, including especially the premonitory phase, which appears to be the critical period in which the pain attack begins and represents the transition point from the interictal phase.  Finding ways to extend the duration of the interictal phase would allow us to prevent the transition of episodic migraine to chronic migraine.
These experiences have led me to improve as a scholar and to become competitive for research funding.  I had the honor of receiving my first competitive extramural grant as a principal investigator in 2019. This year, I was delighted to receive an Honorable Mention from the review committee of University of Arizona Postdoctoral Affairs, as one of four finalists for the 2021 Outstanding Postdoctoral Scholar Award. The recognition and my collective experiences will increase my confidence in competing for future grants, aiding my transition to independent status as my career progresses.  My goal is to pursue studies of high significance that will be impactful in helping the overall efforts of the headache research community to improve therapy for patients with migraine, post-traumatic headache and other craniofacial pain disorders.As a post-doctoral fellow in the laboratory of Dr. Frank Porreca, my research has focused on studying orofacial pain.  My approach has been to use pharmacology, genetics and animal behavior. My professional goal is to establish a research program that focuses on the exploration of neural, immune and hormonal mechanisms that promote migraine pathophysiology disproportionally in women and to uncover mechanisms that can be exploited for the development of new therapies that will help patients suffering from this debilitating and often chronic condition.
Migraine is a common, disabling neurological disorder with a strong genetic component that impairs patients’ quality of life.  Currently available therapies are effective in less than half of people with migraine. During my post-doctoral period, I have published several studies on preclinical assessment of migraine and other underlying headache and craniofacial pain disorders with a goal of understanding mechanisms that may promote pain. One of the problems with preclinical studies of migraine is that we cannot replicate the genetic basis that underlies the human condition. For this reason, surrogate strategies have to be used to model the disorder mechanistically. I recently developed an injury-free model of migraine-like pain by evaluating the effect of inhalational exposure of umbellulone, an agonist at TRPA1 receptors that are found on afferent fibers innervating the cranial meninges.  Umbellulone is the major volatile constituent of Umbellularia californica, commonly known as the “headache tree”.  Anecdotal reports reveal that people with underlying primary headache disorders can develop migraine and cluster headache when exposed to the tree, likely from this volatile substance.  Importantly, however, people without headache disorders do not experience headache attacks with umbellulone suggesting a requirement for pre-existing vulnerability.  I approached this by subjecting mice to repeated episodes of stress, another known trigger of migraine, to induce vulnerability. Repeated episodes of stress induced a “sensitized” state in mice so that a normally subthreshold stimulus, i.e., umbellulone, now produced pain behaviors that were reminiscent of migraine-like pain. I then used this model to study possible mechanisms relevant to migraine and to investigate new anti-migraine therapies.  Using this model, I found that activation of the protease activated receptor 2 (PAR2) receptor could produce migraine-like pain in vulnerable animals and that systemic administration of a monoclonal PAR2 antibody could be an effective preventive migraine therapy. I am currently working with a major pharmaceutical company in their efforts to perform a clinical trial in migraine patients with this antibody.
Currently, I have been using genetically modified mice, CRISPR/Cas9 gene editing as well as opto- and chemogenetic methods to explore the peripheral and central neural circuits that can promote migraine pain and that might contribute to the sexually dimorphic nature of migraine. I have also focused on understanding of the neurobiology of the different phases of migraine, including especially the premonitory phase, which appears to be the critical period in which the pain attack begins and represents the transition point from the interictal phase.  Finding ways to extend the duration of the interictal phase would allow us to prevent the transition of episodic migraine to chronic migraine.
These experiences have led me to improve as a scholar and to become competitive for research funding.  I had the honor of receiving my first competitive extramural grant as a principal investigator in 2019. This year, I was delighted to receive an Honorable Mention from the review committee of University of Arizona Postdoctoral Affairs, as one of four finalists for the 2021 Outstanding Postdoctoral Scholar Award. The recognition and my collective experiences will increase my confidence in competing for future grants, aiding my transition to independent status as my career progresses.  My goal is to pursue studies of high significance that will be impactful in helping the overall efforts of the headache research community to improve therapy for patients with migraine, post-traumatic headache and other craniofacial pain disorders.
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Dr. Shio Kobayashi- Dept. of Immunobiology & BIO5 Institute

4/8/2021

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I have been fascinated since I was an undergraduate by the human immune system, which in its elegance is both a fundamental and complicated system in our body. The system distinguishes the components of foreign pathogens or viruses from our self components and keeps up the pathogen surveillance. If pathogens or viruses invade our body, the immune system mobilizes immune cells and clears these invaders. The invader's information is relayed from cell to cell and is memorized in cells to respond quickly during a future attack, just like human society. But sometimes, this elaborate system mischaracterizes our self components as pieces of hostile foreigners and starts to attack our body. This abnormal condition is called 'autoimmunity'. The trigger of autoimmunity has not been clear despite big efforts by the researchers. 'Why our immune system attacks ourself? What happens in the immune system during an autoimmune disease?’. My journey into immune research is a quest to answer these simple yet profound questions.
 
I have learned immunology under the mentoring of Dr. Takeshi Watanabe and obtained my Ph.D. from Kyoto University in Japan. In my Ph.D. work, I focused on a type of T cells in rheumatoid arthritis (RA), which is one of the autoimmune diseases, and elucidated how T cells contribute to continuous inflammation at the local site in the patients by investigating RA patients’ samples. Through my Ph.D. work, the more I knew about a piece of the immune system, the more I was engrossed in immunology. I gradually desired to apply my knowledge and skills to the treatment of patients.

This passion drove me to work on the five modules CAR (5MCAR) project led by Dr. Michael S. Kuhns (University of Arizona, AZ) and Dr. Thomas Serwold (Joslin Diabetes Center, MA). The 5MCAR technology is based on the chimeric receptor (CAR) technology and aims to target pathogenic T cells. T cells expressing 5MCAR can eliminate only specific T cells via the receptor. We applied 5MCAR technology for the treatment of Type 1 diabetes (T1D), which is an autoimmune disease and is caused by pathogenic autoimmune T cells. Our data showed that 5MCAR expressing T cells eliminated only pathogenic T cells in T1D mouse models and prevented the onset of T1D in the mice. These results indicate that the 5MCAR technology has the potential for the treatment of not only T1D but also diseases caused by pathogenic T cells. We are now trying to apply the 5MCAR technology for the treatment of T-Lymphoma.
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I have had a fulfilling research life at the University of Arizona under the mentorship of Drs. Kuhns and Michael Worobey, support from the university, especially the BIO5 Fellowship, and by Arizona's incredible culture. My journey into immune research is in its prologue. There is a long and rocky road ahead to answer my research questions and apply our technology to clinical studies. However, I am going to continue this scientific quest to impart my knowledge and skills to the patients diagnosed with autoimmune diseases.
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Dr. François Lanoë -Bureau of Applied Research in Anthropology, School of Anthropology

3/18/2021

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am I am an archaeologist and anthropologist, studying the complex and dynamic relationship between humans and their environments. I focus on the settlement of the Americas in modern day Alaska and in the Northwestern Plains.

In Alaska, I am building upon my doctoral work in researching archaeological sites that date to the end of the Ice Age and are among the oldest in North America. I focus on the study of animal bones both visually (zooarchaeology) and chemically (isotope analysis) to understand the changing environments that hunter-gatherers experienced and how they interacted with other species. In this endeavor, I work closely with University of Alaska geoarchaeologist and University of Arizona alumnus Dr. Joshua Reuther.
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In the Blackfoot Early Origins Project, Dr. Nieves Zedeño and I are working with tribes of the Blackfoot Confederacy in Montana and Alberta to understand how the Blackfoot and their ancestors have interacted with their landscape for thousands of years. We train tribal members in field methods, allowing them to pursue rewarding careers with cultural resource management companies. Several University of Arizona graduate students also receive training and develop their own research programs as part of the project. We translate much of our research into educational material to be used by Blackfoot educators, including interactive maps of the Blackfoot ancestral territory and its archaeological record.

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